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Central sleep apnea

Definition

Central sleep apnea is a disorder in which your breathing repeatedly stops and starts during sleep.

Central sleep apnea occurs because your brain doesn't send proper signals to the muscles that control your breathing. This condition is different from obstructive sleep apnea, in which you can't breathe normally because of upper airway obstruction.

Central sleep apnea is less common than obstructive sleep apnea.

Central sleep apnea may occur as a result of other conditions, such as heart failure and stroke. Sleeping at a high altitude also may cause central sleep apnea.

Treatments for central sleep apnea may involve treating existing conditions, using a device to assist breathing or using supplemental oxygen.

Symptoms

Common signs and symptoms of central sleep apnea include:

  • Observed episodes of stopped breathing or abnormal breathing patterns during sleep
  • Abrupt awakenings accompanied by shortness of breath
  • Shortness of breath that's relieved by sitting up
  • Difficulty staying asleep (insomnia)
  • Excessive daytime sleepiness (hypersomnia)
  • Difficulty concentrating
  • Mood changes
  • Morning headaches
  • Snoring

Although snoring indicates some degree of increased obstruction to airflow, snoring also may be heard in the presence of central sleep apnea. However, snoring may not be as prominent with central sleep apnea as it is with obstructive sleep apnea.

When to see a doctor
Consult a medical professional if you experience, or if your partner observes, any signs or symptoms of central sleep apnea, particularly the following:

  • Shortness of breath that awakens you from sleep
  • Intermittent pauses in your breathing during sleep
  • Difficulty staying asleep
  • Excessive daytime drowsiness, which may cause you to fall asleep while you're working, watching television or even driving

Ask your doctor about any sleep problem that leaves you chronically fatigued, sleepy and irritable. Excessive daytime drowsiness (hypersomnia) may be due to other disorders, such as narcolepsy or obstructive sleep apnea.

Causes

Central sleep apnea occurs when your brain fails to transmit signals to your breathing muscles.

Central sleep apnea can be caused by a number of conditions that affect the ability of your brainstem which links your brain to your spinal cord and controls many functions such as heart rate and breathing to control your breathing. The cause varies with the type of central sleep apnea you have. Types include:

  • Cheyne-Stokes breathing. This type of central sleep apnea is most commonly associated with congestive heart failure or stroke. This condition is characterized by a gradual increase and then decrease in breathing effort and airflow. During the weakest breathing effort, a total lack of airflow (central sleep apnea) can occur.
  • Drug-induced apnea. Taking certain medications such as opioids including morphine sulfate (Ms Contin, Avinza, others), oxycodone (Oxycodone HCL, Oxycontin, others) or codeine sulfate may cause your breathing to become irregular, to increase and decrease in a regular pattern, or to temporarily stop completely.
  • High-altitude periodic breathing. A Cheyne-Stokes breathing pattern may occur if you're exposed to a very high altitude. The change in oxygen at this altitude is the reason for the alternating rapid breathing (hyperventilation) and under breathing.
  • Complex sleep apnea. Some people with obstructive sleep apnea develop central sleep apnea while using continuous positive airway pressure (CPAP) for their sleep apnea treatment. This condition is known as complex sleep apnea because it's a combination of obstructive and central sleep apneas.
  • Medical condition-induced central sleep apnea. Several medical conditions may give rise to central sleep apnea of the non-Cheyne-Stokes variety.
  • Idiopathic (primary) central sleep apnea. The cause of this uncommon type of central sleep apnea isn't known. It results in repeated pauses in breathing effort and airflow.

Risk factors

Certain factors put you at increased risk of central sleep apnea:

  • Sex. Males are more likely to develop central sleep apnea than are females.
  • Age. Central sleep apnea is more common among older adults, especially adults older than age 65, possibly because they may have other medical conditions or sleep patterns that are more likely to cause central sleep apnea.
  • Heart disorders. People with atrial fibrillation or congestive heart failure are at greater risk of central sleep apnea. Sleep disordered breathing, such as Cheyne-Stokes breathing and obstructive sleep apnea, may be present in up to 50 percent of people with congestive heart failure.
  • Stroke or brain tumor. These brain conditions can impair the brain's ability to regulate breathing.
  • High altitude. Sleeping at an altitude higher than you're accustomed to may increase your risk of sleep apnea. High-altitude sleep apnea is no longer a problem when you return to a lower altitude.
  • Opioid use. Opioid medications may increase the risk of central sleep apnea.
  • CPAP. Some people with obstructive sleep apnea develop central sleep apnea while using continuous positive airway pressure (CPAP). This condition is known as complex sleep apnea because it is a combination of obstructive and central sleep apneas.

    For some people, complex sleep apnea goes away with continued use of a CPAP device. Other people may be treated with a different kind of positive airway pressure therapy.

Complications

Central sleep apnea is a serious medical condition. Some complications include:

  • Fatigue. The repeated awakenings associated with sleep apnea make normal, restorative sleep impossible. People with central sleep apnea often experience severe fatigue, daytime drowsiness and irritability.

    You may have difficulty concentrating and find yourself falling asleep at work, while watching television or even when driving.

  • Cardiovascular problems. In addition, sudden drops in blood oxygen levels that occur during central sleep apnea may adversely affect heart health.

    If there's underlying heart disease, these repeated multiple episodes of low blood oxygen (hypoxia or hypoxemia) worsen prognosis and increase the risk of abnormal heart rhythms.

Preparing for your appointment

You're likely to start by seeing your family doctor or a general practitioner. However, you may then be referred to a sleep specialist.

Because appointments can be brief and there's often a lot to talk about, it's a good idea to be well prepared for your appointment. Here's some information to help you get ready for your appointment and what to expect from your doctor.

What you can do

  • Bring results of prior sleep studies or other tests with you, or ask that they be given to your sleep specialist.
  • Ask someone, such as a spouse or partner, who has seen you sleeping to come with you to your appointment. He or she will likely be able to provide your doctor with additional information.
  • Write down any symptoms you're experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment.
  • Write down key personal information, including any major stressesor recent life changes.
  • Make a list of all medications, vitamins or supplements that you're taking.
  • Write down questions to ask your doctor.

Your time with your doctor is limited, so preparing a list of questions will help you make the most of your time together. List your questions from most important to least important in case time runs out. For central sleep apnea, some basic questions to ask your doctor include:

  • What's the most likely cause of my symptoms?
  • Are there other possible causes for my symptoms?
  • What kinds of tests do I need? Do these tests require any special preparation?
  • Is this condition temporary or long lasting?
  • What treatments are available, and which do you recommend?
  • How will treating or not treating my central sleep apnea affect my health now and in the future?
  • I have other health conditions. How can I best manage them together?
  • Are there any brochures or other printed material that I can take home with me? What websites do you recommend visiting?

In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask questions during your appointment.

What to expect from your doctor
Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over any points you want to spend more time on. Your doctor may ask:

  • When did you begin experiencing symptoms?
  • Have your symptoms been continuous or occasional?
  • Can you describe your typical sleep schedule?
  • How long do you sleep, and do you sleep soundly?
  • Does anything unusual occur while you're sleeping?
  • Do you know if you snore?
  • How do you feel when you wake up?
  • Do you fall asleep easily during the day?
  • Has anyone ever told you that you stop breathing while you're sleeping?
  • How many times do you wake up at night?
  • Are you short of breath when you wake up at night?
  • Does anything seem to improve your symptoms?
  • Is there anything that seems to worsen your symptoms?
  • Do you have any other medical conditions?
  • What medications, if any, are you currently taking?

Tests and diagnosis

Your doctor may make an evaluation based on your signs and symptoms or may refer you to a sleep specialist in a sleep disorder center.

A sleep specialist can help you decide on your need for further evaluation. Such an evaluation often involves overnight monitoring of your breathing and other body functions during a sleep study called polysomnography.

During polysomnography, you're connected to equipment that monitors your heart, lung and brain activity, breathing patterns, arm and leg movements, and blood oxygen levels while you sleep. You may have a full-night or split-night sleep study.

In a split-night sleep study, you'll be monitored during the first half of the night. If you're diagnosed with obstructive sleep apnea, staff may wake you and give you continuous positive airway pressure for the second half of the night.

Polysomnography can help your doctor diagnose central sleep apnea. It also can help your doctor rule out other sleep disorders, such as periodic limb movements of sleep or narcolepsy, which can cause excessive daytime sleepiness but require different treatment.

Doctors trained in nervous system diseases (neurologists), heart diseases (cardiologists) and others may be involved in evaluating your condition. Doctors may order imaging of your head or heart.

Treatments and drugs

Treatments for central sleep apnea may include:

  • Addressing associated medical problems. Possible causes of central sleep apnea include other disorders, and treating those conditions may help your central sleep apnea. For example, therapy for heart failure may improve central sleep apnea.
  • Reduction of opioid medications. If opioid medications are causing your central sleep apnea, your doctor may gradually reduce your dose of those medications.
  • Continuous positive airway pressure (CPAP). This method, also used to treat obstructive sleep apnea, involves wearing a mask over your nose while you sleep. CPAP is usually the first treatment given for central sleep apnea.

    The mask is attached to a small pump that supplies a continuous amount of pressurized air to hold open your upper airway. CPAP may prevent the airway closure that can trigger central sleep apnea.

    As with obstructive sleep apnea, it's important that you use the device only as directed. If your mask is uncomfortable or the pressure feels too strong, talk with your doctor. Several types of masks are available. Doctors can also adjust the air pressure.

  • Adaptive servo-ventilation (ASV). If CPAP hasn't effectively treated your condition, you may be given ASV.

    Like CPAP, ASV also delivers pressurized air. However, unlike CPAP, ASV adjusts the amount of pressure during inspiration on a breath-by-breath basis to smooth out the breathing pattern. The device may also automatically deliver a breath if you haven't taken a breath within a certain number of seconds.

  • Bilevel positive airway pressure (BPAP). Like ASV, BPAP delivers pressure when you breathe in and a different amount of pressure when you breathe out. Unlike ASV, the amount of pressure during inspiration is fixed rather than variable.

    BPAP can also be configured to deliver a breath if you haven't taken a breath within a certain number of seconds.

  • Supplemental oxygen. Using supplemental oxygen while you sleep may help if you have central sleep apnea. Various devices are available to deliver oxygen to your lungs.
  • Medications. Certain medications, such as acetazolamide (Diamox) or theophylline (Theo-24, Theochron, others), have been used to stimulate breathing in people with central sleep apnea.

    Doctors may prescribe medications to help your breathing as you sleep if you can't take positive airway pressure. Also, some doctors prescribe medications to prevent central sleep apnea in high altitude.

Continuous positive airway pressure (CPAP)

Illustration showing continuous positive airway pressure (CPAP) mask
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To eliminate snoring and prevent sleep apnea, your doctor may recommend a device called a continuous positive airway pressure (CPAP) machine. A CPAP machine delivers just enough air pressure to a ...
Updated: 6/28/2013

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